RESTORIL drug is a member of the class of benzodiazepines known as sleeping pills. It increases the amount of time you spend sleeping and shortens the time it takes to fall asleep. Adults with short-term (often no longer than 7–10 days) insomnia can use RESTORIL.
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Inside The RESTORIL Guide
What is RESTORIL, and What is Restoril Used For?
A prescription sleep medicine is called RESTORIL. Adults with insomnia are treated with RESTORIL for a brief period of time. Insomnia symptoms include difficulty getting asleep and frequent nighttime awakenings.
Due to its potential for abuse and dependence, RESTORIL is classified as a federal restricted substance (C-IV).
Central nervous system (CNS) depressants include benzodiazepines. Benzodiazepines are thought to improve or facilitate the effects of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter.
Restoril Chemical Properties
Restoril (temazepam) is a benzodiazepine hypnotic agent. The chemical name include are 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one.
Restoril Structural Formula
Is It Safe to Buy Restoril Online?
It is safe to get Restoril online after proper consideration of FDA guidelines for purchasing Restoril from a license online pharmacy with a valid prescription from your doctor.
Do Not Take Restoril Drug If You:
- Are allergic to temazepam or other benzodiazepines (like diazepam, alprazolam, or lorazepam)?
- Have severe breathing problems or sleep apnea syndrome
- Have severe liver disease or acute liver failure
- Are pregnant or planning to become pregnant (Pregnancy Category X)
- Are breastfeeding
- Have myasthenia gravis (a neuromuscular disorder)
- Have a history of substance abuse or addiction
- Are taking certain medications that strongly interact with Restoril, including
- Have untreated mental health conditions
- Have acute narrow-angle glaucoma
The effects of temazepam 15 mg and 30 mg were compared to a placebo over a two-week period in sleep laboratory tests. Both total sleep time and sleep latency showed a linear dose-response improvement, with notable drug-placebo differences for the latter at the higher dose and for total sleep time at both levels. Slow-wave sleep was reduced whereas REM sleep remained virtually unaltered.
Restoril Mechanism of Action: Learn How it Works
Imagine your brain as a bustling city at night to get a sense of how Restoril functions. GABA is a naturally occurring, calming transmitter in the city. It is the energy that maintains the peace and quiet in this cerebral city.
A benzodiazepine with hypnotic qualities is RESTORIL. Central nervous system (CNS) depressants include benzodiazepines. Benzodiazepines are thought to improve or facilitate the effects of gammaaminobutyric acid (GABA), an inhibitory neurotransmitter.
Buy Restoril online to get the minimal support this peacekeeping team needs now and again. It’s like giving GABA a loudhailer so it can blast the soothing message through the brain’s congested streets.
Absorption
- Peak plasma time: 2-3 hr
- Peak plasma concentration: 260-210 ng/mL
Metabolism
- Metabolized by CYP3A4 (minor), glucuronic acid conjugation
- Metabolites: Inactive
Elimination
- Half-life elimination: 9.5-12.4 hr
- Excretion: Urine (80-90%)
Rebound Insomnia
Withdrawing hypnotic therapy may result in a temporary condition called “rebound insomnia,” in which the symptoms that prompted benzodiazepine treatment reappear in an intensified version.
Although there was a brief sleep disturbance in certain sleep measures after the higher doses were stopped, there were no discernible effects on daytime alertness or performance during the withdrawal period or after Restoril treatment in the sleep laboratory tests.
Bioavailability, Induction, and Plasma Levels
Measurable plasma concentrations were obtained 10 to 20 minutes after taking a 30 mg Restoril capsule, with peak plasma levels between 666 and 982 ng/mL (mean 865 ng/mL) appearing roughly 1.2 to 1.6 hours (mean 1.5 hours) after treatment.
The third dose of a 30-mg Restoril capsule, administered to participants one hour before bedtime, produced steady-state results (as determined by the achievement of maximal trough concentrations) in a seven-day research. The mean temazepam plasma levels (for days 2–7) were 75±80 ng/mL 24 hours after dose and 260±210 ng/mL 9 hours later.
Elimination Rate of Benzodiazepine Hypnotics and Profile of Common Untoward Effects
INDICATIONS AND USAGE of Restoril
Temazepam, also known as Restoril, is prescribed for the short-term (usually 7–10 days) treatment of insomnia. The prescription should specify that Restoril drug (temazepam) should only be taken for brief periods of time (7 to 10 days) for patients with short-term insomnia.
The final official evaluation of sleep latency was conducted at the conclusion of treatment in the two-week clinical trials that supported efficacy.
Patient Category | Starting Dose | Maximum Dose | Timing |
---|---|---|---|
Adults | 15 mg | 30 mg | 30 mins before bedtime |
Elderly (65+) | 7.5 mg | 15 mg | 30 mins before bedtime |
Liver Impairment | 7.5 mg | 15 mg | 30 mins before bedtime |
Renal Impairment | 7.5 mg | 15 mg | 30 mins before bedtime |
Restoril Usage Warnings:
A primary psychiatric and/or physical condition, or a misconception of sleep status, may be present if insomnia does not go away after 7–10 days of treatment. An undiagnosed mental or physical illness may be the cause of worsening sleeplessness or the appearance of new abnormalities in thought or behavior. Don’t buy Restoril online without prescription.
Risks from Concomitant Use of Opioids
When benzodiazepines, such as Restoril, and opioids are used together, it can cause severe drowsiness, respiratory depression, coma, and even death. Due to these dangers, only provide these medications concurrently to patients for whom no other treatment alternatives are suitable.
Restoril Side effects
The most common Restoril side effects include: drowsiness headache tiredness nervousness dizziness nausea
Restoril Abuse, Misuse, and Addiction
Benzodiazepines, such as Restoril, put users at risk for addiction, abuse, and misuse, which can result in overdose or even death. A higher frequency of serious adverse outcomes, such as respiratory depression, overdose, or death.
It is linked to the abuse and misuse of benzodiazepines, which frequently (though not always) involve the use of doses higher than the maximum recommended dosage and frequently involve concurrent use of other medications, alcohol, and/or illegal substances.
Withdrawal Effects from Restoril
Benzodiazepines, like RESTORIL, can produce severe or life-threatening withdrawal symptoms.
- Avoid abrupt discontinuation or rapid dose reduction of RESTORIL.
- Terminate treatment with RESTORIL by gradually tapering the dosage schedule under close monitoring.
Common Withdrawal Symptoms
- Anxiety
- Insomnia
- Restlessness
- Muscle tension
- Tremors
- Sweating
- Nausea and vomiting
- Headaches
- Dizziness and lightheadedness
- Irritability
Important Considerations:
- All dosages should be individually determined by a healthcare provider
- Never adjust dosage without medical consultation
- Keep track of usage in a medication diary
- Store medication securely at room temperature
- Never share prescriptions with others
What is the Most Important Information I Should Know About RESTORIL?
RESTORIL is a benzodiazepine medicine. Taking benzodiazepines with opioid medicines, alcohol, or other central nervous system depressants (including street drugs) can cause severe drowsiness, breathing problems (respiratory depression), coma and death.
After taking RESTORIL, you may get up out of bed while not being fully awake and do an activity that you do not know you are doing. The next morning, you may not remember that you did anything during the night.
You have a higher chance for doing these activities if you drink alcohol or take other medicines that make you sleepy with RESTORIL. Reported activities include:
- Driving a car (“sleep-driving”)
- Making and eating food
- Talking on the phone o having sex o
- Sleep-walking
Call your healthcare provider right away if you find out that you have done any of the above activities after taking RESTORIL.
Only take RESTORIL if you are able to stay in bed a full night (7 to 8 hours) before you must be active again. Do not take more RESTORIL than prescribed.
Quick FAQs
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What are the ingredients in RESTORIL?
Medicinal ingredient: Temazepam. Non-medicinal ingredients: Ammonium hydroxide, croscarmellose sodium, D&C Red No. 28, FD&C Blue No. 1, FD&C Red No. 40, gelatin, lactose anhydrous, magnesium stearate, microcrystalline cellulose, propylene glycol, red iron oxide (15 mg capsules only), shellac glaze, simethicone, sodium lauryl sulfate, talc, and titanium dioxide.
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What should I avoid while taking RESTORIL?
Alcohol consumption and operating heavy machinery or automobiles should be avoided when using RESTORIL (temazepam), since these activities might greatly raise the risk of accidents because of the sedative effects of the medicine.
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How should I take RESTORIL?
Take RESTORIL exactly as prescribed by your healthcare provider. The typical instructions are:
• Take it right before getting into bed
• Plan for 7-8 hours of uninterrupted sleep
• Swallow the capsule whole with water
• Take on an empty stomach or at least 2 hours after eating